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Anti-CASP8 Polyclonal Antibody

商家询价

产品名称： Anti-CASP8 Polyclonal Antibody

英文名称： Anti-CASP8 Polyclonal Antibody

产品编号： K001600P

产品价格： null

产品产地：北京

品牌商标： solarbio

更新时间： 2025-01-17T10:18:30

使用范围： WB IF

北京索莱宝科技有限公司

联系人 : 索莱宝-龚思雨
地址 : 北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层
邮编 : 101102
所在区域 : 北京
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产品详情

Anti-CASP8 Polyclonal Antibody
品牌：solarbio | 货号：K001600P
商品货号： 商品品牌： 规格 基本售价： 选择规格
K001600P-50ul solarbio 50ul 960.00元 
K001600P-100ul solarbio 100ul 1600.00元

商品货号：	商品品牌：	规格	基本售价：	选择规格
K001600P-50ul	solarbio	50ul	960.00元
K001600P-100ul	solarbio	100ul	1600.00元

英文名称 Anti-CASP8 Polyclonal Antibody
别名 ALPS2B;CAP4;Casp-8;FLICE;MACH;MCH5
应用 WB IF
稀释比例 WB 1:500-2000. IF 1:50-200.
交叉反应 Human Mouse
蛋白分子量 55kDa
Gene ID 841
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human CASP8
性状 液体
Public Immunogen Range Recombinant protein of human CASP8
Subcellular Locations Cytoplasm
Swiss Prot Q14790
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

英文名称	Anti-CASP8 Polyclonal Antibody
别名	ALPS2B;CAP4;Casp-8;FLICE;MACH;MCH5
应用	WB IF
稀释比例	WB 1:500-2000. IF 1:50-200.
交叉反应	Human Mouse
蛋白分子量	55kDa
Gene ID	841
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human CASP8
性状	液体
Public Immunogen Range	Recombinant protein of human CASP8
Subcellular Locations	Cytoplasm
Swiss Prot	Q14790
克隆类型	Polyclonal Antibody
背景资料	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.