MBD1 monoclonal antibody (M03), clone 4F6
产品名称： MBD1 monoclonal antibody (M03), clone 4F6
英文名称： MBD1 monoclonal antibody (M03), clone 4F6
产品编号： H00004152-M03
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant MBD1.
- Immunogen:
- MBD1 (NP_056671, 415 a.a. ~ 508 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- HHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTDLVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDE
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2b Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.08 KDa) .
- MSDS:
Download
- Applications
- Western Blot (Cell lysate)
- MBD1 monoclonal antibody (M03), clone 4F6. Western Blot analysis of MBD1 expression in IMR-32 ( Cat # L008V1 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged MBD1 is 3 ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 4152
- GeneBank Accession#:
- NM_015846
- Protein Accession#:
- NP_056671
- Gene Name:
- MBD1
- Gene Alias:
- CXXC3,PCM1,RFT
- Gene Description:
- methyl-CpG binding domain protein 1
- Omim ID:
- 156535
- Gene Ontology:
- Hyperlink
- Gene Summary:
- DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21. [provided by RefSeq
- Other Designations:
- OTTHUMP00000163504,OTTHUMP00000163506,OTTHUMP00000163507,methyl-CpG binding domain protein 1 isoform PCM1,the regulator of fibroblast growth factor 2 (FGF-2) transcription