FITC标记的LHX5蛋白抗体
产品名称： FITC标记的LHX5蛋白抗体
英文名称： Anti-LHX5/FITC
产品编号： HZ-11870R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-LHX5/FITC Conjugated antibody
FITC标记的LHX5蛋白抗体
| 英文名称 | Anti-LHX5/FITC |
| 中文名称 | FITC标记的LHX5蛋白抗体 |
| 别 名 | LHX 5; Lhx5; LHX5_HUMAN; LIM homeobox 5; LIM homeobox protein 5; LIM/homeobox protein Lhx5; MGC129689. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LHX5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: During development, genetically distinct subtypes of motor neurons express unique combinations of LIM-type homeodomain factors, which regulate cell migration and guide motor axons to establish the fidelity of a binary choice in axonal trajectory. The LIM gene family encodes a set of gene products, which carry the LIM domain, a unique cysteine-rich zinc-binding domain. At least 40 members of this family have been identified in vertebrates and invertebrates, and are distributed into 4 groups according to the number of LIM domains and to the presence of homeodomains and kinase domains. The human LHX5 gene maps to chromosome 12q23-q24 and encodes a 402 amino acid protein. The hippocampus contains the neural circuitry, which is crucial for cognitive functions such as learning and memory. LHX5 regulates precursor cell proliferation and neuronal differentiation and migration during hippocampal development. Function: Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system. Subcellular Location: Nucleus. Tissue Specificity: Expressed in fetal brain and in various regions of the adult central nervous system including the spinal cord, the thalamus, and the cerebellum. Similarity: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains. Database links: UniProtKB/Swiss-Prot: Q9H2C1.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
在发育过程中，遗传上不同的运动神经元亚型表达LIM型同源域因子的独特组合，这些因子调节细胞迁移，并引导运动轴突建立轴突轨迹中二元选择的逼真度。LIM基因家族编码一组基因产物，携带LIM结构域，一个独特的富含半胱氨酸的锌结合结构域。在脊椎动物和无脊椎动物中已经鉴定出该家族的至少40个成员，并且根据LIM结构域的数量以及同源结构域和激酶结构域的存在被分成4组。人类LHX5基因定位于染色体12q23-Q24，编码402个氨基酸蛋白。海马包含神经回路，它对学习和记忆等认知功能至关重要。LHX5在海马发育过程中调节前体细胞增殖和神经元分化和迁移。